Prof. Xuetao Cao’s group published a new review on Immunity
Source：Juan Liu
2016-09-05
Recently, Prof. Xuetao Cao (Academician of Chinese Academy of Engineering, Director of Chinese Academy of Medical Sciences) and Associate Prof. Juan Liu and Cheng Qian (National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University) has published a new review in Immunity about the function and mechanisms of post-translational modificationsin the regulation of innate immuneresponseand inflammation (Liu J. et al, Post-translational modification control of innate Immunity. Immunity, 2016 Jul 19;45(1):15-30) .
PRR-triggered activation of innate immune responses is crucial for host defense against foreign microorganisms, and a delicate regulatory network is required to ensure the most proper signaling outcome to avoid unwanted inflammatory diseases. Post-translational modifications have been increasingly shown to regulate PRR-dependent innate immunity and inflammatory response via affecting the activity and function of innate sensors and signaling molecules. In recent years, remarkable advances have been made in our understanding of the PTM control of critical signaling molecules in the innate immunity and inflammatory responses.
In this review, Cao and colleagues focus on the roles of different forms of PTMs (such as phosphorylation, polyubiquitination, methylation, acetylation, etc.) in controlling PRR-triggered innate immunity and inflammatory responses via their effects in protein activity, cellular translocation and physical interaction. The emerging roles of PTMs in the pathogenesis and potential treatment of infectious and inflammatory immune diseases are also discussed. They also give insightful comments on the intriguing questions that challenges further investigations in this field, such as the unknown function of PTMs in innate immune regulation, the cellular and signaling selectivity of PTM, the crosstalk of different types of PTMs.
PRR-triggered activation of innate immune responses is crucial for host defense against foreign microorganisms, and a delicate regulatory network is required to ensure the most proper signaling outcome to avoid unwanted inflammatory diseases. Post-translational modifications have been increasingly shown to regulate PRR-dependent innate immunity and inflammatory response via affecting the activity and function of innate sensors and signaling molecules. In recent years, remarkable advances have been made in our understanding of the PTM control of critical signaling molecules in the innate immunity and inflammatory responses.
In this review, Cao and colleagues focus on the roles of different forms of PTMs (such as phosphorylation, polyubiquitination, methylation, acetylation, etc.) in controlling PRR-triggered innate immunity and inflammatory responses via their effects in protein activity, cellular translocation and physical interaction. The emerging roles of PTMs in the pathogenesis and potential treatment of infectious and inflammatory immune diseases are also discussed. They also give insightful comments on the intriguing questions that challenges further investigations in this field, such as the unknown function of PTMs in innate immune regulation, the cellular and signaling selectivity of PTM, the crosstalk of different types of PTMs.
